Authors
Akerele N. N., Rafiu M. O., Emorinken A., Ahmed S. D., Erohubie C. E., Akerele J. M., Azubike C. O.
Abstract
Collapsing focal segmental glomerulosclerosis (cFSGS) is a histological lesion commonly seen on kidney biopsy in
individual with Human Immunodeficiency Virus Associated Nephropathy (HIVAN). Collapsing focal segmental
glomerulosclerosis (cFSGS), also known as collapsing glomerulopathy (CG), is currently classified as a distinct
clinicopathological variant of FSGS. It is an important cause of End Stage Renal Disease (ESRD).Collapsing FSGS
is not a single disease entity but rather it is a distinctive expression of renal parenchymal injury, which may result
from a multitude of causes. While HIV infection is a common aetiology of secondary causes of cFSGS. Other
infectious agents have also been implicated, but quite rare. We are reporting a case of a 30-year-old HIV negative
woman who presented to the Nephrology clinic with complaints of generalized body swelling of 2 months duration
following an uneventful pregnancy. Patient had hyperthyroidism, but she was euthyroid at the time of her
presentation. Her urinalysis showed 4+ of proteinuria. We made an initial assessment of Nephrotic syndrome of
queried etiology to rule out autoimmunine disease. Screening for HIV was negative, serology for HBsAg, and antiHCV were negative. Antinuclear antibodies, anti-double stranded DNA, anti- SSA, anti-SSB and extractable nuclear
antibodies were negative. She was commenced on oral telmisartan, torsemide, atorvastatin, Slow K (potassium
supplement on account of hypokalaemia), and carbimazole. The result of the kidney biopsy showed presence of focal
segmental glomerulosclerosis of the collapsing variant. She was treated with prednisolone and mycophenolate
mofetil. She is being followed up at the Nephrology clinic.
individual with Human Immunodeficiency Virus Associated Nephropathy (HIVAN). Collapsing focal segmental
glomerulosclerosis (cFSGS), also known as collapsing glomerulopathy (CG), is currently classified as a distinct
clinicopathological variant of FSGS. It is an important cause of End Stage Renal Disease (ESRD).Collapsing FSGS
is not a single disease entity but rather it is a distinctive expression of renal parenchymal injury, which may result
from a multitude of causes. While HIV infection is a common aetiology of secondary causes of cFSGS. Other
infectious agents have also been implicated, but quite rare. We are reporting a case of a 30-year-old HIV negative
woman who presented to the Nephrology clinic with complaints of generalized body swelling of 2 months duration
following an uneventful pregnancy. Patient had hyperthyroidism, but she was euthyroid at the time of her
presentation. Her urinalysis showed 4+ of proteinuria. We made an initial assessment of Nephrotic syndrome of
queried etiology to rule out autoimmunine disease. Screening for HIV was negative, serology for HBsAg, and antiHCV were negative. Antinuclear antibodies, anti-double stranded DNA, anti- SSA, anti-SSB and extractable nuclear
antibodies were negative. She was commenced on oral telmisartan, torsemide, atorvastatin, Slow K (potassium
supplement on account of hypokalaemia), and carbimazole. The result of the kidney biopsy showed presence of focal
segmental glomerulosclerosis of the collapsing variant. She was treated with prednisolone and mycophenolate
mofetil. She is being followed up at the Nephrology clinic.
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